Working-memory fMRI reveals cingulate hyperactivation in euthymic major depression
نویسندگان
چکیده
منابع مشابه
Age-Related Frontal Hyperactivation Observed across Different Working Memory Tasks: An fMRI Study
PURPOSE To evaluate patterns of activation, convergence and divergence of three functional magnetic resonance imaging (fMRI) Working Memory (WM) tasks in two different age groups. We want to understand potential impact of task and subjects' age on WM activations as well as most important areas with regard to WM functions. MATERIALS AND METHODS Thirty-five healthy volunteers completed visual, ...
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OBJECTIVE Prior studies showed that subjects with major depression have deficits in hippocampal-based verbal declarative memory (e.g., recall of a paragraph) and in hippocampal and prefrontal cortical functioning and structure. The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife maj...
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Converging evidence suggests a central role for dysfunction of the subgenual anterior cingulate cortex (sgACC) in the pathophysiology of major depressive disorder (MDD). Underlying mechanisms may include altered GABAergic function. Expression of somatostatin (SST), an inhibitory neuropeptide localized to a subset of GABA neurons, has been shown to be lower in the dorsolateral prefrontal cortex ...
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Introduction: Recent functional imaging studies suggest alterations in cortico-limbic circuit connectivity in depression. Moreover, these functional connectivity (fc) changes were found to correlate with symptom severity and normalised upon antidepressant treatment (1). The direction of these fc changes is however debated with one group showing increased default network connectivity and another...
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ژورنال
عنوان ژورنال: Human Brain Mapping
سال: 2009
ISSN: 1065-9471,1097-0193
DOI: 10.1002/hbm.20702